Older age, especially over 55 years
Genetic predispostion: BRCA1/2, ATM, p53, CHEK2, PTEN, CDH1
Early menarche (< 12 y), late menopause (> 55 y)
No childbirth or late childbirth
Race: higher risk in whites, higher mortaliy in African-Americans
Family history of breast cancer
Previous history of breast cancer
History of proliferative benign breast diseases
History of previous breast biopsy
History of recent OCP use or combination HRT
Exposure to radiation
Obesity, lack of exercise, poor diet and alcohol use
Breast lump history:When and how was the mass first noted?
Change in size (any relation to menstrual cycle)?
Tender vs nontender
Nipple discharge (bloody/serous/milky, uni-/ bilateral, single/multiple ducts, spontan./induced)
Skin changes: dimpling, redness
Date of LMP and length and regularity of cycles
History of trauma, previous breast bx. or procedure
Family history of breast ca (relation and age)
Constitutional symptoms:Fever, weakness, weight loss
Metastases symptoms:Cough, bone pain, back pain, hemoptysis, dyspnea, jaundice, RUQ pain, pathological fractures