Breast cancer risk factors:

Older age, especially over 55 years

Genetic predispostion: BRCA1/2, ATM, p53, CHEK2, PTEN, CDH1

Early menarche (< 12 y), late menopause (> 55 y)

No childbirth or late childbirth

Race: higher risk in whites, higher mortaliy in African-Americans

Family history of breast cancer

Previous history of breast cancer

History of proliferative benign breast diseases

History of previous breast biopsy

History of recent OCP use or combination HRT

Exposure to radiation

Obesity, lack of exercise, poor diet and alcohol use

Breast lump history:

When and how was the mass first noted?

Change in size (any relation to menstrual cycle)?

Tender vs nontender

Nipple discharge (bloody/serous/milky, uni-/ bilateral, single/multiple ducts, spontan./induced)

Skin changes: dimpling, redness

Date of LMP and length and regularity of cycles

History of trauma, previous breast bx. or procedure

Family history of breast ca (relation and age)

Constitutional symptoms:

Fever, weakness, weight loss

Metastases symptoms:

Cough, bone pain, back pain, hemoptysis, dyspnea, jaundice, RUQ pain, pathological fractures